A bone biopsy is a procedure performed in a hospital to investigate the nature of a bony lesion. A doctor takes a small piece from the bony lesion in most case using x-rays or a CT scanner using a special type of needle.
A soft tissue biopsy is a procedure performed in a hospital to investigate the cause of a soft tissue lump. A doctor takes a small piece(s) of tissue from the lump in most cases under ultrasound guidance using a special type of needle.